Section I: General questions about CBD
1- What is CBD?
Two kinds of the cannabis sativa plant; hemp and marijuana. Both plants produce chemical compounds called cannabinoids. Cannabidiol (CBD) is complex chemical compound from which contains over 100 active cannabinoids. It also contains terpenes, which have anti-inflammatory properties, and are regarded as increasing the efficacy of cannabinoids.
CBD is short for cannabidiol and is derived from the Cannabis plant, specifically the hemp portion. Thecannabis plant features two natural elements: THC and CBD, CBD being the non-psychoactive portion of the plant. CBD contains over 100 active cannabinoids and terpenes, which offer anti-inflammatoryproperties and a slew of other beneficial physiological and psychological effects.
2- How does CBD work?
CBD works by interacting with the body’s endocannabinoid system, the regulatory biological system that’s comprised of naturally occurring cannabis-like-molecules. These “endocannabinoids” function like neurotransmitters, transferring messages throughout the body to help maintain homeostasis (the state the body seeks to maintain while adjusting to conditions that are best for its survival). These cannabinoids then interact with two known receptors: CB1 and CB2, which are mainly found in the brain and in white blood cells.
3- What are the health benefits of using CBD?
CBD has emerged over the past few years in high regards due to its renowned health benefits. Early research has suggested a plethora of positive effects associated with its usage, including assuaging anxiety, appeasing schizophrenic symptoms, curtailing seizures and epileptic episodes, reducing body inflammation, minimizing aches and pains, alleviating insomnia, and eliciting a sense of calmness and relaxation. And while additional studies are being conducted, most data, analyses, and evidence have netted widespread acclaim.
4- What are the reported side effect of CBD?
A 2017 World Health Organization report found that CBD in its pure state is safe, well-tolerated by humans and animals and not likely to cause physical dependence or abuse. And according to the National Institutes of Health (NIH), 1,500 mg of CBD has been safely taken by mouth daily for up to 4 weeks. But just like any supplement or product, there are always a few risks associated with taking CBD that you should be aware of:
- Side effects. Dry mouth, low blood pressure, lightheadedness, and drowsiness have been reported, according to the NIH, as have signs of liver injury, though the latter is less common.
- Limited research. CBD’s classification as a Schedule I drug severely limits the number of studies researchers can conduct on the compound. And while the research does indicate ample positive health benefits, there are still a few unknowns surrounding what conditions CBD can help treat and how much people would need to take for it to be effective. That means if you’re taking CBD to treat a certainailment, you could be taking too much or too little.
- Inadequate regulation. There are no standards in place for producing, testing, or labeling CBD products, which makes any type of federal oversight or quality control impossible. In fact, Penn Medicine researchersfound that nearly 70% of CBD products purchased from the internet contained either more CBD than the label indicated — which could be dangerous — or less CBD than what was indicated, which could also negate any potential benefits. Many products also contained significant amounts of THC (the psychoactive element of cannabis that makes you feel euphoric)
- Drug interactions. Not much is known about how CBD could interfere with other medications, but experts say it may hinder how quickly the body breaks down a variety of prescription medications, which can increase side effects. It can also enhance the sedative properties of herbs and supplements that are known to cause sleepiness or drowsiness. Talk with your doctor or a pharmacist to confirm whether anything you take regularly could be affected by CBD.
- Pre- and post-natal unknowns. There’s not enough evidence available yet about whether it’s safe to take CBD while you’re pregnant or nursing. Experts advise avoiding it just to be safe.
3- What is the difference between CBD distillate and CBD Isolate?
There are two main forms of CBD on the market: CBD distillate and CBD isolate. CBD isolate is CBD in its purest form: isolated cannabidiol. A CBD distillate contains different cannabinoids, terpenes, and plant materials. However, the CBD distillate could be refined more to become a CBD isolate.
6- Is CBD legal in all 50 states?
Yes, at AlivianceTM,we follow the US Farm Bill 2018, which was signed into law on December 20, 2018, making hemp-based Cannabidiol (CBD) products legal to grow, manufacture, distribute, and transport in all 50 states at the federal level. Certain states which have previously passed legislation restricting its use then changed their state laws to comply with the federal ruling. Read The Farm Bill signed into law on December 20, 2018 here US Farm Bill 2018.
7- Is it legal to ship CBD to all 50 states?
Yes. CBD became federally legal in 2018.The United States Post Office has issued an updated guidance (June 2019) stating that they will ship CBD products to all 50 states, provided they are US Farm Bill 2018 compliant and that shippers keep testing records of all shipments sent. Other carriers are on board as well, particularly for wholesale orders. Currently, US law prohibits shipping of CBD products outside of the United States.
8- What is the difference between hemp seed oil, CBD full spectrum oil, and CBD isolate?
Hemp seed oil comes from hemp seeds, which contain negligible amounts of CBD. The most concentrated CBD comes from the flowers or buds, but other plant parts contain lower levels of CBD. To concentrate the CBD, the plants are extracted, and the oil is distilled. The oil is considered full spectrum because it comes from the whole plant and contains other cannabinoids such as CBG, CBN, CBV, THC, THCA, THCV, terpenes, flavonoids, and phytochemicals.
To further purify CBD into an isolate,high levelsof distillation and extraction methods are used until the CBD is 99.7% pure or higher and appears as a white crystalline powder.
9- What is the “Entourage Effect”?
The “entourage effect” is the powerful effect of combining CBD and other cannabinoids such as Terpenes, found only in Full Spectrum CBD oil. The “entourage effect” is the result of terpenes causing CBD to perform even better than it would in a CBD Isolate.
Other cannabinoids, terpenoids, and flavonoids may be part of an entourage effect. The entourage effect is considered a possible cannabinoid system modulator and is achieved in pain management.
Wikipedia (https://en.wikipedia.org/wiki/Entourage_effect)—NEVER USE WIKIPEDIA AS A CITED SOURCE SINCE IT CAN BE EDITED AND MANIPULATED BY ANYONE
CBD In Clinical and Non-Clinical Studies
10- Can CBD help with inflammation and pain?
The Arthritis Foundation recently published preliminary research suggesting that CBD may help treating arthritis pain.
Daniel Clauw, MD, a professor at the University of Michigan in Ann Arbor and an expert in chronic pain, doesn’t write off CBD’s potential benefits and recommends it to some of his patients.
“A recent trial showed CBD alone was effective in [the treatment of] knee OA, and it appears as though it is very safe,” he says. “Nearly all potential side effects of cannabinoids are from THC, not CBD.”
11- Can CBD help with Anxiety and Sleep?
This question was the focus of a recently published clinical study (Pubmed:2019). This study was conducted to determine whether CBD helps improve sleep and/or reduce anxiety in a clinical population. A large retrospective case series at a psychiatric clinic involving clinical application of CBD for anxiety and sleep complaints as an adjunct to usual treatment. The retrospective chart review included monthly documentation of anxiety and sleep quality in 103 adult patients.
In this sample of the case study, 72 adults presented with primary concerns of anxiety (n = 47) or poor sleep (n = 25). Anxiety scores decreased within the first month in 57 patients (79.2%) and remained decreased during the study duration. Sleep scores improved within the first month in 48 patients (66.7%) but fluctuated over time. In this chart review, CBD was well tolerated in all but 3 patients. Conclusion: Cannabidiol may offer benefits for anxiety-related disorders. Controlled clinical studies are needed.
Author Affiliations 1 Department of Psychiatry, University of Colorado, Denver 2 Department of Naturopathic Medicine, Wholeness Center, Fort Collins, CO 3 North Range Behavioral Health, Greeley, CO 4 School of Social Work, Colorado State University College of Health and Human Sciences, Fort Collins Corresponding Author Scott Shannon, MD (firstname.lastname@example.org)
Section II: Questions About Our Products:
1- Do your CBD products contain marijuana, and will they get me “high”?
No. At AlivianceTM, we ensure that our CBD oil is always US Farm Bill 2018 compliant, meaning it must contain less than 0.3% THC (Tetrahydrocannabinol, the active psychoactive ingredient in marijuana) by dry weight. This level of THC is not substantial enough to have a psychoactive effect on the brain nor deliver a “high”. We also test all our incoming raw materials to ensure they are compliant before we accept them into our facility.
2- Is this product tested on animals?
No, we do not test our products on animals. We test on ourselves; we are the guinea pigs!
3- How can I trust that your products are of the highest quality?
At AlivianceTM, our products are all formulated by top scientists, flavorists, and engineers. We initially derive our products for ourselves, our closest friends, and family in order to get honest feedback; when they utilize this information to tweak our products to optimal efficiency. We are always looking improve our formulations.
We only purchase USDA Organic, natural, Kosher, and Halal raw materials. We keep all certificates on file from our growers and extractors, and we test all incoming CBD at a third-party lab before we accept it into our facility. All of our partners are fully vetted, and we make sure to perform third party cannabinoid testing on all our finished products to ensure safety and efficacy before they are shipped to our customers. We also make it a priority to listen to feedback from our customers and discover ways we can improve our existing products as well as create new ones that our customers would like to see.
4- What does it mean that your products are more bio-available?
The biggest scientific challenge in the CBD industry is transporting its properties to the brain receptors. Because it’s an oil and a large molecule, CBD is unable to enter the water-soluble bloodstream easily. (Cannabinoid Delivery Systems for Pain and Inflammation Treatment, Bruni et al)
Based on the latest studies, the following is the approximate percentage of CBD which reaches the CB1 and CB2 receptors in the brain:
- Topicals – 35%-45% – bio-availability also increases on the skin since it contains water and oil layers, plus there’s an advantage of putting the CBD precisely where you require treatment.
- Tinctures -12-35% – quick absorption under or on the tongue increases bio-availability, but the rest is wasted during the first pass effect.
- Edibles – 6-15%, the lowest, due to the “first pass effect” where the long process of digestion and the stomach acid causes less than a tenth of the CBD to be absorbed and make it to the brain.
At AlivianceTM, our products are micro-emulsified to overcome the water/oil barrier and to reduce the size of the CBD particles. This allows our products to reach the bloodstream faster with a higher potency than most CBD products on the market today. Microemulsion of CBD Affects Bioavailability
5- Why do you use a variety of essential oils in your products?
Similar to CBD, essential oils are also extracted and formulated from plants for a more holistic approach to support heath and well-being. These special oils are derived from a particular plant’s scent and flavor, constituting the “essence” portion of “essential.” Having been used around the world for almost 100 years, studies and research have shown certain properties in essential oils can interact with your body when applied topically or inhaled through various methods, a.k.a aromatherapy. And just like our premium CBD oil, our revolutionary approach of pairing our CBD with other essential oils can help amplify the health benefits you’ll experience. Our concoctions are natural, safe, and effective, so you never have to worry and can experience medicinal benefits that’ll help you live your best life.